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Sofia Hult Lundh1, Nathalie Nilsson1, Rana Soylu1, Deniz Kirik2 and Åsa Petersén1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.2Brain Repair and Imaging in Neural Systems (BRAINS) Unit, Department of Experimental Medical Science, Lund University, Lund SE-221 84, Sweden.Human Molecular Genetics 22: 3485-3497 (2013)A

https://www.huntington-research.lu.se/hypothalamic-expression-mutant-huntingtin-contributes-development-depressive-behavior-bac-transgenic - 2024-11-17

Linda Holmquist Mengelbier is a paediatric cancer researcher who now, in parallel to her cancer effort, has started to work with the neurodegenerative disorders Huntington disease and ALS. Her focus in the cancer field has been on the embryonal pediatric solid tumors neuroblastoma and Wilms tumor. Neuroblastoma is a sympathetic nervous system tumor derived from the neural crest, whereas Wilms tumo

https://www.huntington-research.lu.se/team/linda-holmquist-mengelbier-phd - 2024-11-17

Soylu-Kucharz R, Adlesic N, Davidsson M, Björklund T, Björkqvist M and Petersén Å. bioRxiv 2023.03.04.530949; First published March 4, 2023, https://doi.org/10.1101/2023.03.04.530949 Abstract Huntington’s disease is a fatal neurodegenerative disorder caused by an expanded CAG triplet repeat in the huntingtin (HTT) gene. Previous research focused on neuropathology in the striatum and its associatio

https://www.huntington-research.lu.se/mutant-huntingtin-expression-hypothalamus-promotes-ventral-striatal-neuropathology - 2024-11-17

Published 7 November 2023 Curious about HD research and wish to learn more? The European Huntington Association/Moving Forward Team is inviting you to a webinar in Norwegian on 22 November. Astri Arnesen, the President of the European Huntington Association, will speak about international HD research, Lasse Pihlstrøm, a Norwegian HD neurologist and researcher, will address HD studies and trials in

https://www.huntington-research.lu.se/article/hd-webinar-22-november-2023 - 2024-11-17

Published 28 November 2023 The European Huntington Association/Moving Forward Team’s webinar in now available on our site! You find it under Talks & Movies:Talks & Movies

https://www.huntington-research.lu.se/article/watch-webinar - 2024-11-17

Published 14 December 2023 The National meeting for HD is a yearly event arranged by the patients’ organization RHS. This year, 2023, it took place in Gothenburg on 30 November. All talks at the meeting are available on RHS website; only in Swedish.You find Åsa Petersén’s research update about 13 minutes into the film. To access the video, go to RHS website:RHS website

https://www.huntington-research.lu.se/article/petersen-gives-research-update-national-meeting-hd-sweden - 2024-11-17

Published 6 February 2024 Every spring, Huntington Disease Center in Lund traditionally hosts an information night on Huntington disease. This year is no exception! The program is set for the evening:Staff from the clinical team and representatives from the patients’ organization, RHS, as well as HD researchers, will give talks about different aspects of the the disease and the current research. A

https://www.huntington-research.lu.se/article/welcome-info-night-hd-22-april-2024 - 2024-11-17

Dalene Skarping K, Arning L, Petersén Å, Nguyen HP and Gebre-Medhin S.Sci Rep. 2024;14(1):4300. Published 2024 Feb 21. doi:10.1038/s41598-024-54277-5AbstractDNA mismatch repair (MMR) is thought to contribute to the onset and progression of Huntington disease (HD) by promoting somatic expansion of the pathogenic CAG nucleotide repeat in the huntingtin gene (HTT). Here we have studied constitutional

https://www.huntington-research.lu.se/attenuated-huntingtin-gene-cag-nucleotide-repeat-size-individuals-lynch-syndrome - 2024-11-17

Lilja Andersson P, Juth N, Petersén Å, Graff C and Edberg AE.Lund University, Sweden.Nursing Ethics 20: 189-199 (2013)AbstractThe aim of this study was to describe the experiences of undergoing a presymptomatic genetic test for the hereditary and fatal Huntington’s disease, using a case study approach. The study was based on 18 interviews with a young woman and her husband from the decision to und

https://www.huntington-research.lu.se/ethical-aspects-undergoing-predictive-genetic-testing-huntingtons-disease - 2024-11-17

Published 21 March 2024 Sofia Bergh, PhD student in TNU, gave two presentations on Huntington disease on 11 and 12 March 2024 during the NMT Days.This is an annual event, arranged by the Faculty of Science, the Faculty of Medicine and the Faculty of Engineering at Lund University. A week of talks and demonstrations on a variety of topics show today’s research, and students in upper secondary schoo

https://www.huntington-research.lu.se/article/bergh-presented-nmt-days - 2024-11-17

Published 21 March 2024 Åsa Petersén gave a talk about Huntington disease and her research for the patients' organization, RHS, in Stockholm on 12 March 2024, where she was invited.

https://www.huntington-research.lu.se/article/petersen-gave-hd-talk-stockholm - 2024-11-17

In 2024, Jennifer moved from Sydney, Australia to Lund, Sweden to start her PhD studies at the TNU, supervised by Pof. Åsa Petersén. In utilizing novel AAV-vectors and crossbreeding of animal models, Jennifer’s project aims to elucidate the specific hypothalamic circuitries important for the control of metabolism and emotion, with relevance to Huntington’s Disease, Amyotrophic Lateral Sclerosis an

https://www.huntington-research.lu.se/team/jennifer-oraha-phd-student - 2024-11-17

Published 3 May 2024 Sofia Bergh's talk from the NMT days is now available online. See more on the Talks & Movies page.

https://www.huntington-research.lu.se/article/see-sofia-berghs-talk-hd - 2024-11-17

Published 31 May 2024 Sofia passed her half time review on 28 May 2024. Sofia Bergh presented her work titled "Cellular and molecular mechanisms of hypothalamic pathology in Huntington disease and the amyotrophic lateral sclerosis/frontotemporal dementia disease spectrum" before the audience and the reviewers Niels Henning Skotte, research group leader, Department for Drug Design and Pharmacology,

https://www.huntington-research.lu.se/article/congratulations-sofia-bergh - 2024-11-17

Published 4 June 2024 For the second time, the European Huntington Association/Moving Forward initiative for the Nordic countries will be hosting a webinar on research updates. The Webinar will be held on 11th June, from 18:00 CET to 19:15 CET. You need to register beforehand to be able to join.Registration link: https://us02web.zoom.us/meeting/register/tZEkdeyupz4oH9KRCnkguo_KMuS0Y6…Åsa Petersén

https://www.huntington-research.lu.se/article/webinar-research-updates-nordic-countries - 2024-11-17

Published 4 July 2024 Oskar Simonsson har completed his Master's studies and passed with Distinction. Oskar has been with TNU since the end of October 2023 to work on his Master's thesis. In the end of May he presented his work "Effects of TDP-43 overexpression in oxytocin neurons on neuropathology and metabolism in mice". Congratulations to your Master of Science in Biomedicine, Oskar!

https://www.huntington-research.lu.se/article/congratulations-oskar - 2024-11-17

Published 28 August 2024 We are honoured to announce that Åsa Petersén has received a two-year grant from Hjärnfonden, The Swedish Brain Foundation, for the project The importance of variations in the CAG repeat for Huntington disease.The awarded amount for the two years is SEK 1 600 000.

https://www.huntington-research.lu.se/article/new-grant-hjarnfonden - 2024-11-17

Lundh SH, Soylu R and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.PLoS ONE 7(12): e51168 (2012).AbstractMetabolic and psychiatric disturbances occur early on in the clinical manifestation of Huntington’s disease (HD), a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin (HTT) gene. Hypot

https://www.huntington-research.lu.se/expression-mutant-huntingtin-leptin-receptor-expressing-neurons-does-not-control-metabolic-and - 2024-11-17

Published 30 August 2024 Mahmoud A. Pouladi, Åsa Petersén, Huu Phuc Nguyen, Jiří Klempíř and A. Nazlı Başak. Together with researchers from Germany, Canada, Turkey and the Czech Republic Åsa Petersén was awarded the JPND grant for the project Delineating the role of HTT Cis-Variants in the pathogenesis of Huntington disease. In Sweden the grant  is funded by Vetenskapsrådet, the Swedish Research C

https://www.huntington-research.lu.se/article/jpnd-project-kickoff-istanbul - 2024-11-17

By jenny [dot] mansson [at] med [dot] lu [dot] se (Jenny Månsson) - published 16 September 2024 Åsa Petersén will participate in the HD patients' organization's national meeting later in September. The patients’ organization, RHS, is inviting you to the national meeting in Gothenburg on 26 September 2024. Åsa Petersén will give an overview of the current HD research and the day will include inform

https://www.huntington-research.lu.se/article/rhs-national-meeting-2024 - 2024-11-17